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Sublingual absoption what literally means 'under the tongue', from Latin, refers to the pharmacological route of administration by which drugs diffuse into the blood through tissues under the tongue.
The principle behind sublingual absorption is simple. When a chemical comes in contact with the mucous membrane beneath the tongue, or buccal mucosa, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first pass metabolism" in the liver before entering the general circulation.
Sublingual absorption allows medicine to be absorbed quickly and directly by the blood vessels under the tongue. This method lets the medicine have a more direct access to the blood circulation in the patient’s body and consequently leads to a systematic distribution and administration of the drug.
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